Supplementary Figure 3B shows that siRNA-mediated silencing of FRK led to decreased cellular invasion of the H358-S and other NSCLC cells. Next, we studied the effects of FRK knockdown on EGFR phosphorylation levels. We did not observe any significant change in the phosphorylation status of EGFR at both Y1197 and Y1068 upon silencing of FRK (Figure 6C). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.