Aged mice with systemic glucose intolerance and hyperinsulinemia show elevation of aortic NADPH oxidase-2 (Nox2) expression, while in vitro glucose and insulin challenge increases Nox2 and ROS levels in coronary microvascular endothelial cells, promoting cellular senescence along with elevation of p53 (118). The gene discussed is CYBB; the disease is Hyperinsulinemia.