Interestingly, the Dahl/SS model of heart failure is associated with upregulation of the Wnt signaling inhibitor secreted frizzled-related protein-1 (SFRP1), which protects against ventricular dilation and hypertrophy (29), as well as increased expression of the transporter of large neutral amino acids (SLC7A5). The gene discussed is SLC7A5; the disease is heart failure.