Three genes linked to inhibition of cardiac hypertrophy were upregulate, viz., DKK3 (Dickkopf-3) (83), FBXO32 (encoding E3 ligase, Fbxo32) (84), and GADD45B, which blocks MKK7-induced JNK activation (85). This evidence concerns the gene FBXO32 and cardiac hypertrophy.