Similarly, EZH2 is also found to act as a co-activator of other critical transcription factors, such as TCF/β-catenin and the DNA repair protein PCNA-associated factor in colorectal cancer (CRC), β-catenin and ERα in breast cancer, to promote the transcription of their target genes, respectively [16, 17]. Here, EZH2 is linked to breast carcinoma.