KRAS and breast carcinoma: Besides, many other transcription factors have also been identified to affect the expression of EZH2 gene, including EWS-FLI1 in Ewing tumors [62], MEK- ERK-ELK1 in pancreatic cancer, triple negative and ERBB2 positive breast cancer [63, 64], KRAS mutations and downstream ERK or Akt in non-small cell lung cancer [65], hypoxia-induced HIF-1α in breast cancer [66], and NF-κB in T-cell leukemia [67].