To date, despite the marked T cell senescence that characterizes APDS, no patients with pulmonary pneumocystis pneumonia (PCP) or invasive aspergillosis have been reported, but interestingly one of two patients reported with a PTEN mutations causing an “APDS-like” syndrome contracted PCP at the age of 4 months and the other was reported to have suffered from “pulmonary aspergillosis,” although further details were not supplied (9). This evidence concerns the gene PTEN and activated PI3K-delta syndrome.