Several scoring systems have been widely used in clinical practice to evaluate the risk of early occurrence of severe ischemic stroke after TIA or minor stroke, including ABCD2 (A for age, B for blood pressure, C for clinical feature, D for duration of the symptoms, and another D for diabetes), ABCD3 (the presence of ≥2 TIA symptoms within 7 days added to the ABCD2 score), and ABCD3-I (the presence of abnormal findings on neuroimaging further added to the ABCD3 score). This evidence concerns the gene ABCD3 and Stroke.