PD pathogenesis involves multiple pathways and mechanisms, such as alpha-synuclein- (Spillantini et al., 1998), tau (Lei et al., 2010), and amyloid beta (Gomperts et al., 2008) misfolding, mitochondrial dysfunction (Schapira, 2008), oxidative stress (Blesa et al., 2015), calcium dyshomeostasis (Rivero-Ríos et al., 2014), axonal transport deficits (Lamberts et al., 2015), and neuroinflammation (Wang et al., 2015). Here, SNCA is linked to Parkinson disease.