It is thought that hypercholesterolemia can enhance the activities of γ-secretase and β-secretase, facilitate the metabolism of amyloid precursor protein (APP), aggravate Aβ deposition, promote the formation of senile plaques and then lead to AD (Kuo et al., 2015; Loke et al., 2017). The gene discussed is APP; the disease is Hypercholesterolemia.