82% of tumour specimens demonstrate altered methylation in at least 4 of the top 5 frequent altered candidates including caudal type homeobox 1 (CDX1), FBP1, transmembrane protein 171 (TMEM171), ganglioside induced differentiation associated protein 1 like 1 (GDAP1L1), and cadherin, EGF LAG seven-pass G-type receptor (CELSR3) [87]. Here, TMEM171 is linked to neoplasm.