BCL2 and breast cancer: Forced FBP1 expression in lung cancer stem cells and breast cancer or FBP2 expression in gastric cancer increased apoptosis by reducing the Bax/Bcl-2 ratio, inducing poly ADP-ribose polymerase (PARP), caspase-3 and caspase-9 activation and suppressing endogenous ROS scavenging systems such as superoxide dismutase (SOD) [12, 19, 25].