In breast cancer cells, FBP1 limited the efficient removal of diseased mitochondria and reduced the expression of hypoxia-induced factor 1α (HIF1α), BCL2/adenovirus E1B 19 kDa interacting protein 3-like (BNIP3L/NIX), and BCL2/adenovirus E1B 19 kDa interacting protein 3 (BNIP3), which disrupts BNIP3/NIX-Bcl-2 complex formation under normal conditions but promotes complex formation between Bcl-2 and Beclin 1 [19]. The gene discussed is HIF1A; the disease is breast carcinoma.