While SRD5A1 was up regulated by DHT and TBECH-γδ, DPTE and hydroxyflutamide down regulated SRD5A1. It has been previously shown that SRD5A1 is an androgen response gene and that its expression is up regulated by androgen treatment in prostate cancer cells51. This evidence concerns the gene SRD5A1 and Familial prostate cancer.