Novel T-ALL potential drivers were detected: mutations in BMPR1A, FREM2 and PIK3CD. BMPR1A (bone morphogenetic protein receptor, type 1A) is a polyposis associated gene—a type 1A transmembrane serine/threonine kinase listed in the cosmic cancer gene census of genes functionally linked to cancer and PIK3CD is a subunit of phosphatidylinositol-4,5-bisphosphate 3-kinase a key member of the PTEN-PI3 kinase pathway. This evidence concerns the gene FREM2 and acute lymphoblastic leukemia.