Until now, it was thought that among B-cell neoplasms BRAF V600E mutation is almost entirely restricted to HCL [2, 49–53], though individual BRAF V600E-mutant cases of chronic lymphocytic leukemia, prolymphocytic leukemia [54], classical Hodgkin lymphoma [55], and SMZL [56, 57] were also documented. This evidence concerns the gene BRAF and splenic marginal zone lymphoma.