In our cohort TNFAIP3 was the most frequently mutated gene in EMZL (31%) as it was in the meta-analysis, which showed that TNFAIP3 was mutated in 25% of EMZL cases (Fig. 6a, b), which was significantly more common in comparison to SMZL and LPL (p ≤ 0.01 and ≤0.05, respectively, Fisher’s exact test), but not to NMZL, where TNFAIP3 was mutated in 15% of studied cases. Here, LPL is linked to nodal marginal zone B-cell lymphoma.