To elucidate the functional significance of TLX in prostate cancer growth upon androgen-deprivation stress, we then generated stable TLX-transduced clones in AR-positive prostate cancer cell lines (including LNCaP, VCaP, and LAPC-4) for in vitro and in vivo growth phenotype studies (Fig. 2a). The gene discussed is AR; the disease is prostate carcinoma.