In this study, iso-α-acids supplementation reduced body weight gain and epididymal fat weight (Fig. 1), and improved several metabolic parameters such as AST, ALT, urea nitrogen, phospholipase, and triglycerides (Table 1), Since it is reported that activation of PPARs improve these circulating factors27–29, iso-α-acids might have protective effects on internal organs damaged in obesity. Here, GPT is linked to obesity due to melanocortin 4 receptor deficiency.