In univariate analysis of overall survival among surgical patients, older age (≥65 years), alcoholism, presence of diabetes mellitus, presence of ascites, high AFP level, larger tumor (>3 cm) and multi-nodularity (>3 nodules), poor performance status, presence of vascular invasion and ALBI grade 2–3 were associated with decreased survival (all p < 0.05, Table 4). This evidence concerns the gene AFP and diabetes mellitus.