To confirm that Peli1 in B cell protect against the autoimmunity in lupus-like disease, we constructed the mixed bone marrow (BM) chimeric mice by reconstituting the lethal dose irradiated B cell-deficient μMT mice with the mixed BMs from μMT mice and Peli1 WT/KO mice (μMT: Peli1 WT/KO = 5: 1) (Fig. 3a). The gene discussed is PELI1; the disease is Autoimmunity.