SAHA has been shown to abrogate TGF-β1-induced lung fibroblast activation and collagen expression [36] and significantly reduce collagen deposition in a murine model of bleomycin-induced pulmonary fibrosis [19,20], suggesting promising antifibrotic potential, however the underlying molecular mechanisms are not clear yet. This evidence concerns the gene TGFB1 and pulmonary fibrosis.