IL4 and asthma: There were a few articles have confirmed this point, such as, Ezzat et al. found the mean and median of OX40L levels were dramatically higher in asthmatic children during acute attacks children than in children with moderate mild asthma exacerbations [31] and Siddiqui et al. showed the number of OX40, OX40L and IL-4 were significantly increased in subjects with mild asthma compared with healthy controls [1].