Consistent with the impaired invasion and migration of MCL cells, phosphorylated FAK was suppressed in Z-138 and Mino cells treated with 2 or 4 μM UNC2250 for 2 h, and total RhoA was suppressed in Z-138 and Mino cells treated with 2 or 4 μM UNC2250 for 12 h (Fig. 3d). This evidence concerns the gene RHOA and mantle cell lymphoma.