To determine whether reduced NF-κB activation in untreated NOD2 G208R sarcoidosis patient (IB) decreases inflammatory cytokines expression, mRNA levels for IL-8, TNF-A, IL-6 genes were assessed by quantitative RT-PCR (qRT-PCR) in monocytes and macrophages in basal condition or in response to either MDP or LPS from control subjects or family members. The gene discussed is NOD2; the disease is sarcoidosis.