The frequencies of the remainder of the autoantibodies, including anti-Ro52/TRIM21, anti-p53, anti-KLHL 12, anti-HK 1, anti-GW182, anti-YB1, anti-Ge1, anti-Ago2, anti MIT3, anti-LKM, anti-SLA, anti-sp100 and anti gp210 were similar between PBC-AIH OS and PBC alone groups (Table 3). The gene discussed is KLHL31; the disease is autoimmune hepatitis.