In contrast, significantly elevated serum ALT (median: 62.0 in PBC-AIH OS vs 37 in PBC alone; P = 0.01) and serum IgG (median: 17.6 in PBC-AIH OS vs 12.1 in PBC alone; P = 0.01) were observed in patients with PBC-AIH OS; the majority of whom were receiving medical therapy/immunosuppressants. The gene discussed is GPT; the disease is primary biliary cholangitis.