Notably, a recent study in a renal fibrosis model showed that an increase in functional KCa3.1 expression causes increased cell proliferation and that pharmacological blockade of KCa3.1 by TRAM-34 targets cell cycle arrest in the G0/G1 phase, which prevents fibroblast proliferation in renal fibrosis [12]. This evidence concerns the gene KCNN4 and renal fibrosis.