UMOD and Polyuria: Using GlatmTg(CAG-A4GALT) Fabry model mice with polyuria, we have demonstrated that mTALs, especially in the IS, were the main tubules that were affected and that TAL dysfunction—an inability to concentrate urine—as a result of decreased expression of core molecules (Na+-K+-ATPase, UMOD, and NKCC2) induced water- and salt-loss phenotypes.