Fabry disease is an X-linked hereditary disease caused by mutations in GLA (α-galactosidase A) gene that encodes the lysosomal enzyme, GLA (1), and it is characterized by the systemic accumulation of glycosphingolipids, especially globotriaosylceramide (Gb3), in the lysosomes of various cell types (2). The gene discussed is GLA; the disease is X-linked disease.