However, it is remarkable that even though a NOD2 polymorphism showed up as related to epidemiopathogenic forms, adding it to the five SNPs selected in this study did not improve the distribution (data not shown) in spite of previous associations between this gene and MAP shedding for this breed (Ruiz-Larrañaga et al., 2010a; Küpper et al., 2014) and its more similar disease in humans, Crohn's disease (Hugot et al., 2001; Ogura et al., 2001). Here, NOD2 is linked to Crohn disease.