A study has shown an association of aspirin with lower colorectal cancer risk only in individuals carrying the minor T allele (rs6983267), and a specificity of this association for the CTNNB1 (beta-catenin)-positive WNT signaling activated tumor subtype.67 Together with the gene-environment interaction analysis,93 integrated analyses of drugs, germline genetics, and somatic molecular alterations will further shed lights on inter-individual differences in drug effects. The gene discussed is CTNNB1; the disease is colorectal cancer.