CXCL1 and Hepatic fibrosis: As shown in Figure 4A–C, blockade of CXCL1 with a neutralizing antibody or genetic disruption of the Cxcl1 gene markedly attenuated liver fibrosis in the HFD+1B ethanol-fed mice relative to IgG-treated or WT controls, as shown by the reduced Sirius Red–positive area and fibrosis-related gene expression.