Specifically, genetic activation of Nrf2 in mice by knockdown of its repressor Kelch-like ECH-associated protein-1 (Keap1) has been reported to inhibit liver steatosis and NASH caused by an MCD diet,25, 26 but genetic activation of Nrf2 in mice by knockdown of Keap1 has also been reported to increase NASH caused by a HF diet27 and to increase insulin resistance and liver steatosis when crossed onto a Lepob/ob background.28 Here, NFE2L2 is linked to fatty liver disease.