Our finding that TBE-31 treatment reverses insulin resistance in mice that have been fed chronically an HFFr diet is consistent with a report that treatment of 6-week-old diabetic db/db mice with the Nrf2 activator CDDO-Im for 10 weeks increased glucose clearance and lowered plasma insulin levels during an oral GTT.31 Here, NFE2L2 is linked to Insulin resistance.