NFE2L2 and steatosis: H&E staining of liver sections revealed that consumption of the HF30Fr diet for 16 weeks stimulated greater steatosis and inflammation in Nrf2-/- mice than in their wild-type counterparts (Figure 15A), and that TBE-31 treatment of mice on the HF30Fr diet decreased steatosis and inflammation in wild-type livers, but not in Nrf2-/- livers (Figure 15B).