As anticipated, the inability of TBE-31 to suppress NASH in Nrf2-/- mice was associated with higher levels of hepatic malondialdehyde, oxidized protein, and GSSG than in Nrf2+/+ mice (Figure 19C–E) suggesting that TBE-31 did not suppress oxidative stress caused by the HF30Fr diet in Nrf2-/- mice. The gene discussed is NFE2L2; the disease is metabolic dysfunction-associated steatohepatitis.