It is known that Nrf2-/- mice are more sensitive than Nrf2+/+ mice to streptozotocin-induced diabetes, and that pharmacologic activation of Nrf2 with sulforaphane (SFN) can inhibit the development of diabetes,46, 47 but it is not known whether activation of Nrf2 in wild-type mice after diabetes has been induced by physiological stimuli (ie, chronic overnutrition) can mitigate disease. Here, NFE2L2 is linked to diabetes mellitus.