Because oxidative stress contributes to NASH, researchers have examined whether loss of NF-E2 p45-related factor 2 (Nrf2, encoded by NFE2L2) increases susceptibility to the disease because Nrf2 is a master regulator of cellular redox homeostasis that orchestrates adaptation to intracellular redox perturbation.19 This evidence concerns the gene NFE2L2 and metabolic dysfunction-associated steatohepatitis.