Most reported genes associated with chronic pancreatitis that have been identified up to now code for proteins linked to the protease-antiprotease system of acinar cells, such as the cationic and anionic trypsinogen (PRSS1 and 2), chymotrypsinogen C (CTRC), carboxypeptidase A1 (CPA1), or the Kasal-type 1 protease inhibitor (SPINK1) [133]. This evidence concerns the gene CPA1 and chronic pancreatitis.