ALDH2 and early-onset autosomal dominant Alzheimer disease: Consequently, many diseases and health problems can be related to ALDH2 mutation, whose carriers were associated to myocardial infarction [66], impaired myocardial function in rodents and humans [65, 67, 68], hypertension [69], blood pressure variation in East Asians [70], non-insulin-dependent diabetes mellitus due to the maternal ALDH2 [71, 72], a higher incidence of Alzheimer’s disease in Asian patients with the inactivating ALDH2*2 mutation [73–75], increase of esophageal cancer risk no matter of alcoholic beverage drinkers or not [76].