This is the anti-proliferative role of ALDH1A1 because actively proliferating cells are more subject to cytotoxic drugs and so loss of ALDH1A1 contributes to the sensitization of ovarian carcinoma cells to chemotherapy [53] although a study showed the difference due to interplay between ALDH1A1 and the stemness-associated gene SOX2 [40]. The gene discussed is ALDH1A1; the disease is ovarian carcinoma.