There are a variety of lncRNAs in the urine of bladder cancer patients, including HOTAIR, HOX-AS-2, the MALAT1, SOX2, OCT4 HYMA1, LINC00477, LOC100506688, and OTX2-AS1. Knockdown of HOTAIR in bladder cancer cell lines will reduce invasion and migration. This evidence concerns the gene POU5F1 and urinary bladder cancer.