Major dataabout this issue derive from a retrospective study that reviewed 119 patients witheither preexisting autoimmune disease and/or a history of irAEs during priortreatment with ipilimumab treated with anti–PD-1 therapy for advanced melanoma(30% of patients had active symptoms and 38% were on immunosuppressive agents): 38%of patients experienced a flare of their autoimmune, most of wich were mild inintensity. The gene discussed is PDCD1; the disease is melanoma.