The hypoxemia status causes the systemic inflammation, associated [9] with Interferon gamma (IFNγ), the tumor necrosis factor-alpha (TNF-α) [10], and oxidative stress [11] leading to direct neuronal damage, as well as depletion of neurotransmitters because of the dysfunction of oxygen-dependent enzymes in chronic obstructive pulmonary disease (COPD) [12]. Here, TNF is linked to chronic obstructive pulmonary disease.