In addition, the AUC values of p27 gene in ESAC, ESCC, GC and CRC were 0.82 (CI: 0.78–0.85; sensitivity: 0.76; specificity: 0.86; Figure 11B), 0.85 (CI: 0.82–0.88; sensitivity: 0.69; specificity: 0.84; Figure 11C), 0.74 (CI: 0.70–0.78; sensitivity: 0.53; specificity: 0.82; Figure 11D) and 0.81 (CI: 0.78–0.84; sensitivity: 0.61; specificity: 0.84; Figure 11E), respectively. Here, CDKN1B is linked to esophageal squamous cell carcinoma.