CDKN1B and metastatic malignant neoplasm in the lymph nodes: The overall odd ratios (ORs) indicated that a decreased expression of p27 protein was positively related to lymph node metastasis (OR: 2.15, 95% CI: 1.57–2.96, P < 0.0001; I2 = 69.4%, P < 0.0001; Figure 6A), distant metastasis (OR: 2.02, 95% CI: 1.12–3.63, P = 0.019; I2 = 50.4%, P = 0.073; Figure 6B) and pathology grading (OR: 2.14, 95% CI: 1.75–2.62, P < 0.0001; I2 = 17.2%, P = 0.221; Figure 7) in patients with DTCs.