In GC group, correlations of p27 protein expression with lymph node metastasis (OR: 2.05, 95% CI: 1.38–3.04, P < 0.0001) and pathology grading (OR: 2.08, 95% CI: 1.62–2.69, P < 0.0001) were observed; while no significant associations between p27 protein expression and distant metastasis was found (OR: 1.19, 95% CI: 0.74–1.91, P = 0.463). Here, CDKN1B is linked to gastric cancer.