Among the 62 studies, 54 studies [8, 10–62] followed survival, and 37 studies [8, 13, 15–20, 24, 28–30, 36, 39, 40, 44–47, 49–51, 54, 55, 57–61, 63–70] investigated the relationships of p27 protein expression with lymph node metastasis, distant metastasis and pathology grading. Here, CDKN1B is linked to metastatic malignant neoplasm in the lymph nodes.