Meanwhile, the luciferase report assay demonstrated that miR-203 mimic reduced the luciferase activities of reporter plasmids carrying the binding site of miR-203 on the mRNA of PCAT3 or PCAT9, but the change was diminished in the mutant reporter (Figure 4C–4F), suggesting that miR-203 can function as a sponge to repress PCAT3 and PCAT9 in PCa. The gene discussed is PCGEM1; the disease is posterior cortical atrophy.