SOX2 and breast cancer: Many of the genes regulated have previously been shown to correlate with aggressiveness of breast cancer such as CD24, SOX2, Slug, Twist1, CD-133, N-Cadherin, E-Cadherin, FOXC2, ABCG2, c-Myc, IL8, IL6, and IKKβ (activating NF-κB signaling).