Importantly, EBV infection was also significantly correlated with high level of PD-L1 expression at TI area (mean IRS value: 2.4 [EBV+] vs 1.7 [EBV-]; OR = 2.57, 95% CI 1.13–5.82, p = 0.024) (Figure 2C), which may be responsible to the prognosis distinction between EBV+ and EBV- patients. The gene discussed is CD274; the disease is Epstein-Barr virus infection.