NF-κB, an important transcription factor presenting in most cell types, is known to be one of the key signaling involved in regulation of a large number of inflammatory mediators including asthma [10, 24] Based on these, in this study, we investigated the potential mechanisms whereby tulobuterol patch regulated the airway inflammation by focusing on the activation of syk/NF-κB signaling. Here, NFKB1 is linked to asthma.