As shown in Table 3, the unilateral effect of the PTGS2 rs5275 polymorphism did not significantly change the risk of developing cancer (OR = 0.934, P = 0.264), although the unilateral effect of NSAID use decreased this risk significantly (OR = 0.769, P < 0.001), supporting the conclusion in the study by Nago M et al. [13]. Here, PTGS2 is linked to cancer.