In the study of the CYP46A1 rs754203 polymorphism, we found that the adjusted OR by stratification was slightly higher than the crude OR, although both were larger than 1 with P values smaller than 0.05, suggesting that the CYP46A1 rs754203 polymorphism was significantly associated with the increased AD risk in the overall population. This evidence concerns the gene CYP46A1 and Alzheimer disease.