Furthermore, previous reports have shown that the mutations on Von Hippel-Lindau (VHL), Polybromo-1 (PBRM1) and BRCA1 associated protein-1 (BAP1) are the most common somatic mutations in ccRCC which induces the occurrence and development of ccRCC [25]. Here, PBRM1 is linked to nonpapillary renal cell carcinoma.