The antibody-drug conjugate, glembatumumab vedotin, in which a fully human monoclonal antibody against GPNMB is linked to the potent cytotoxin, monomethyl auristatin E, has been approved by the Food and Drug Administration for phase II clinical trials in stage III or IV melanoma and GPNMB-expressing metastatic triple negative breast cancer [57, 58]. The gene discussed is GPNMB; the disease is melanoma.