To confirm the involvement of SOCS4 in the pro-tumor effects of miR-1290, plasmid carrying shRNA targeting SOCS4 (sh-SOCS4) or control shRNA (sh-NC) was co-transfected with anti-miR-1290 or anti-miR-NC into SPC-A1 cells for further experiments. Here, SOCS4 is linked to neoplasm.