CDKN2B and acute myeloid leukemia: Although the methylation of the 5 ́ promoter region of genes, which leads to transcriptional silencing, is the major mechanism of CDKN2B gene inactivation in acute myeloid leukemia (AML), homozygous deletion or intragenic mutation mechanism of CDKN2B inactivation in AML was reported rarely (9-11).