The result of aberrant methylation of CDKN2B in different AML subtypes result showed higher incidence of methylated CDKN2B in M2 subtype (P=0.035), lower incidence of methylated CDKN2B in M3 (P=0.005) and M4 subtypes (P=0.001) Figure 3B This study revealed a significant correlation between hemoglobin level (Hb) and methylation in M1 and M5 subtypes (P=0.015, P=0.047 respectively). Here, CDKN2B is linked to acute myeloid leukemia.