Taking this into consideration, further research is required in order to differentially characterize the roles of CRP isoforms (pCRP, facilitator, versus mCRP, effector) in CVD onset and progression, and the binding ligands to circulating pCRP which can lead to CRP dissociation and induction of local inflammation in order to develop more potent and orally bioavailable “CRP inhibitors” for the treatment of inflammation and atherosclerosis. This evidence concerns the gene CRP and atherosclerosis.