TLR2 and neurodegenerative disease: Since CD45low microglia express majority of phagoptosis genes including TLR2 (65), while CD45high CNS MPs more highly express DAM-specific and fAβ phagocytic receptors, we propose that the distinct phagocytic receptor profiles of CD45low and CD45high CNS MPs may reflect an overall pro-phagocytic and Aβ-clearing and potentially neuroprotective function for CD45high CNS MPs in neurodegenerative disease and aging.