In fact, due to its importance in adult neurogenesis and neuroinflammation, manipulation of fibroblast growth factor 2 (FGF2)/FGFR1 signaling has been a focus of therapeutic development for neurodegenerative disorders, such as AD, multiple sclerosis (MS), Parkinson's disease and traumatic brain injury (Woodbury and Ikezu, 2014). This evidence concerns the gene FGFR1 and multiple sclerosis.