In fact, due to its importance in adult neurogenesis and neuroinflammation, manipulation of fibroblast growth factor 2 (FGF2)/FGFR1 signaling has been a focus of therapeutic development for neurodegenerative disorders, such as AD, multiple sclerosis (MS), Parkinson's disease and traumatic brain injury (Woodbury and Ikezu, 2014). Here, FGFR1 is linked to Alzheimer disease.