Transcription factors responsible for EMT are ZEB1, SNAI and TWIST.36 An overexpression of SNAI2 is shown in Rf-FTMs, together with an upregulation of the cell-surface protein N-cadherin, which correlates with high risk of SCC invasion via EMT-like mechanisms.37 In SCC, the tumour tissue is surrounded by reactive stroma, made up mostly of CAFs, known for their expression of α-SMA. The gene discussed is CDH2; the disease is neoplasm.