SerpinB4 is described as a biomarker of cancer and known to be strongly upregulated in SCC indicative of a poor prognosis.44,45 Although the process is not yet fully understood, SerpinB4 also acts as an EMT promoter.46 It is expressed by both epithelial cells and fibroblasts upon oncogenic Ras activation.47 Interestingly, in this study SerpinB4 is strongly upregulated in the Pf-FTMs. This evidence concerns the gene SERPINB4 and cancer.