NHERF1 and adenocarcinoma: However, NHERF1 is early lost and weakly re-expressed during the adenoma-to-adenocarcinoma transition [8, 12, 27, 35], thus playing potential antinomic roles as tumor suppressor, when it maintains a proper membrane localization, or tumor promoter when its expression is lost or mislocalized in the cytoplasm and nucleus [7, 9].