NHERF1 and colorectal carcinoma: The two drugs induced CRC cell cycle arrest without significant apoptosis (Fig. 3c) [5, 6] and increased low-endogenous NHERF1 levels, as well as its ectopic cytoplasmic/nuclear subcellular distribution, although at a higher extent in pyrvinium vs FH535-treated cells (Fig. 3b, d).