Then we performed ChIP assays to determine whether β-catenin regulates NHERF1 via recruiting key transcriptional mediators of the Wnt pathway like TCF1, also called transcription factor 7 (TCF7), and TCF4 also called transcription factor 7-like 2 (TCF7L2), both of which involved in CRC carcinogenesis [1, 2]. The gene discussed is TCF7; the disease is colorectal carcinoma.