These data have relatively explained the heterogeneous pattern of NHERF1 observed in primary CRC [9–11], where membranous expression of NHERF1 is usually lost in dysplastic adenomas, and either absent or low/ectopically re-expressed thorough the cytoplasm and nuclei in approximately half of differentiated adenocarcinomas [12, 13]. This evidence concerns the gene NHERF1 and adenocarcinoma.