NHERF1 and colorectal carcinoma: To our knowledge, this is the first report disclosing NHERF1 as a major survival driver in settings of β-catenin-depleted CRC cells which adopt a cytostatic viable phenotype and a unique proteomic signature centred around autophagy and energy metabolism processes (i.e., ribosome biogenesis, spliceosome and RNA transport, oxidative stress and fatty acid degradation).