By physically tethering several cancer-related proteins, such as β-catenin [8], the tyrosine-kinase receptors PDGFR (platelet-derived growth factor receptor) [32] and EGFR (epidermal growth factor receptor) [33], some Wnt-ligand engaged receptors of the Frizzled (FZD) family [34], the tumor suppressor phosphatases PTEN (phosphatase and tensin homolog) [35] or PHLPP (PH leucine-rich repeat protein phosphatase) [36], NHERF1 engages in various functional complexes promoting specific phenotypic outcomes in cancer progression and metastatic organotropism [13, 27, 31]. The gene discussed is NHERF1; the disease is cancer.