We also observed borderline statistically significant interactions between recurrent GERD symptoms and rs12465911 (P = 1.70 × 10–7 for interaction), rs2341926 (P = 1.83 × 10–7 for interaction), and rs13396805 (P = 3.58 × 10–7 for interaction) at chromosome 2q23.3 (RND3-RBM43). Here, RND3 is linked to gastroesophageal reflux disease.