HDGFL2 and infection: RDTs targeting the P. falciparum-specific antigen histidine-rich protein 2 (HRP2) remain the most sensitive and robust tests for diagnosis of P. falciparum malaria, in part due to poorer LODs of tests for the other commonly used antigen, lactate dehydrogenase (LDH), as well as HRP2 accumulation during infection [13].