From the evidence presented so far, it is likely that there are two predominant roles, 1) in the modulation of CSD and therefore migraine aura, in particular with the evidence supporting ASIC1a, and 2) in the modulation of nociceptive signaling from the meninges, in which there is the emerging role for ASIC3 in trigeminovascular nociception. This evidence concerns the gene ASIC3 and migraine disorder.